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KMID : 1134820100390050655
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Journal of the Korean Society of Food Science and Nutrition
2010 Volume.39 No. 5 p.655 ~ p.661
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Inhibitory Effects of Angiotensin Converting Enzyme a nd α-Glucosidase, and Alcohol Metabolizing Activity of Fermented Omija (Schizandra chinensis Baillon) Beverage
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Cho Eun-Kyung
Cho Hea-Eun
Choi Young-Ju
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Abstract
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The nutraceutical role of fermented omija (Schizandra chinensis) beverage (FOB) was determined through the analysis of fibrinolytic and alcohol metabolizing activities, nitrite scavenging activity, and angiotensin converting enzyme and α-glucosidase inhibitory effects. Firstly, FOB increased fibrinolytic activity in a dosedependent manner and indicated angiotensin converting enzyme inhibitory activity of 94.8% at 20% FOB (0.6 ㎎/㎖). In addition, the inhibitory activities of FOB on α-amylase and α-glucosidase were determined to be 100% at 100% FOB (3 ㎎/㎖) and 49% at 60% FOB (1.8 ㎎/㎖), respectively. Nitrite scavenging activity of FOB was about 96.1%, 72.3%, and 68.3% on ? 1.2, 3.0, and 6.0 at 100% FOB, respectively. To determine influence of FOB on alcohol metabolism, the generating activities of reduced-nicotinamide adenine dinucleotide (NADH) by alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) were measured. Facilitating rate of ADH activity was 70.3% at 50% FOB, but ALDH activity was not affected. These results revealed that FOB has a strong alcohol metabolizing activity, and fibrinolytic and nitrite scavenging activities and exhibits the angiotensin converting enzyme, α-amylase, and α-glucosidase inhibitory activities.
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KEYWORD
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Schizandra chinensis Baillon, fibrinolytic and alcohol metabolizing activities, nitrite scavenging activity, angiotensin converting enzyme and α-glucosidase inhibitory effects
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